I've just setup node inspector for debugging. I created basic a test app based on the documentation on nodejitsu.com. I've written an overview here too.

Install node inspector globally:

npm install node-inspector -g  

Run your app in debug mode using the --debug flag:

node --debug index.js  

Run the inspector in a new terminal specifying the port of your app:

node-inspector --web-port=8080  

The port is whatever port you are running your app on, the example above is 8080.

Visit the debugger app by visiting http://127.0.0.1:8080/

Voila.